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A recent review of one of my grant applications commented on the ‘rediscovery of tropomyosin’. I was tempted to write back in my rebuttal to the reviewer that I didn’t realise it had been lost. Uncharacteristic maturity prevailed and I resisted the temptation, but I was struck by the underlying observation that research on the str- ture and function of tropomyosin has been somewhat invisible, particularly in terms of the cytoskeleton isoforms. So, how can it be that one of the two major components of the actin filament has been so thoroughly overlooked? I suspect that the answer is disappointingly pedestrian. Whereas the biochemistry of the 1980s revealed the potential of tropomyosin isoforms to diversify the function of actin filaments, the subsequent disenchantment with isoform biology in general in the 1990s inhibited growth of this field. With the development of more sophisticated experimental - proaches we are now seeing a growing realisation of the importance of tropomyosin in regulating actin filaments beyond its pivotal role in muscle contraction. The opportunity to edit this book came at a time when we had written several reviews on different aspects of tropomyosin function and I had just finished the background reading for a comprehensive review of tropomyosin biology. I realised that the field was simply beyond the capacity of any one person to do the field j- tice.

Biomedicine. --- Biomedicine general. --- Medicine. --- Médecine --- Tropomyosin. --- Tropomyosins. --- Tropomyosins --- Tropomyosin --- Microfilament Proteins --- Muscle Proteins --- Cytoskeletal Proteins --- Biopolymers --- Contractile Proteins --- Proteins --- Polymers --- Amino Acids, Peptides, and Proteins --- Macromolecular Substances --- Chemicals and Drugs --- Animal Biochemistry --- Human Anatomy & Physiology --- Health & Biological Sciences --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Microfilament proteins --- Muscle proteins --- Health Workforce --- Biomedicine, general.

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The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information.

Medicine & Public Health. --- Oncology. --- Cancer Research. --- Medicine. --- Médecine --- Cancérologie --- Cancer --Chemotherapy. --- Cancer --Treatment. --- Cancer --- Receptors, Gastrointestinal Hormone --- Receptor Protein-Tyrosine Kinases --- Cell Physiological Processes --- Diseases --- Receptors, Growth Factor --- Biochemical Processes --- Receptors, Cell Surface --- Cell Physiological Phenomena --- Biochemical Phenomena --- Receptors, Peptide --- Protein-Tyrosine Kinases --- Chemical Processes --- Chemical Phenomena --- Membrane Proteins --- Phenomena and Processes --- Protein Kinases --- Phosphotransferases (Alcohol Group Acceptor) --- Proteins --- Amino Acids, Peptides, and Proteins --- Phosphotransferases --- Chemicals and Drugs --- Transferases --- Enzymes --- Enzymes and Coenzymes --- Receptor, Epidermal Growth Factor --- Signal Transduction --- Neoplasms --- Medicine --- Health & Biological Sciences --- Oncology --- Treatment --- Chemotherapy --- Chemotherapy. --- Treatment. --- Cancer therapy --- Cancer treatment --- Therapy --- Cancer research. --- Tumors --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Antineoplastic agents

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Deals with developments in such topics as mechanisms of hormonal carcinogenesis, epidemiology and risk factors, hormone production by tumor tissue and hormonal sensitivity of the latter, genesis, dichotomy and endocrinology of cancer in females, and pharmacogenomics and proteomics in oncoendocrinology.

Biomedicine. --- Cancer Research. --- Medicine. --- Oncology. --- Médecine --- Cancérologie --- Breast Neoplasms -- drug therapy. --- Breast Neoplasms -- physiopathology. --- Cancer -- Endocrine aspects. --- Estrogen Receptor Modulators -- pharmacology. --- Receptors, Estrogen -- physiology. --- Receptors, Progesterone -- physiology. --- Cancer --- Estrogen Receptor Modulators --- Receptors, Estrogen --- Breast Neoplasms --- Drug Therapy --- Receptors, Progesterone --- Pharmacology --- Physiology --- Receptors, Steroid --- Hormone Antagonists --- Breast Diseases --- Biological Science Disciplines --- Therapeutics --- Neoplasms by Site --- Skin Diseases --- Receptors, Cytoplasmic and Nuclear --- Neoplasms --- Natural Science Disciplines --- Hormones, Hormone Substitutes, and Hormone Antagonists --- Analytical, Diagnostic and Therapeutic Techniques and Equipment --- Transcription Factors --- DNA-Binding Proteins --- Disciplines and Occupations --- Physiological Effects of Drugs --- Skin and Connective Tissue Diseases --- Proteins --- Diseases --- Chemicals and Drugs --- Pharmacologic Actions --- Amino Acids, Peptides, and Proteins --- Chemical Actions and Uses --- Oncology --- Medicine --- Health & Biological Sciences --- Endocrine aspects --- Endocrine aspects. --- Cancer endocrinology --- Hormonal aspects of cancer --- Hormonal aspects --- Cancer research. --- Cancer research --- Clinical sciences --- Medical profession --- Human biology --- Life sciences --- Medical sciences --- Pathology --- Physicians --- Tumors

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Complement has long been regarded as a pivotal effector arm of the innate immune response, eliciting important immunoregulatory functions in the context of inflammation and also serving as a vital link between the innate and adaptive immune response. In the post-genomic era, our knowledge of the innate immune system is enriched by findings that point to novel functions that do not strictly correlate with immunological defense and surveillance, immune modulation or Inflammation. Several studies indicate that complement proteins exert functions that are either more complex than previously thought, or go well beyond the innate immune character of the system. The advent of high-throughput platforms for genome and proteome-wide profiling, together with the enormous amount of raw genetic information that has accumulated in the databases, have stirred new expectations in biomedical research. They have led complementologists to revisit established biological systems, such as the complement system, from a global and integrative perspective. Complement research is now faced with the challenge of trying to integrate isolated biochemical pathways into complex gene and protein regulatory circuits. In this respect, scientists from around the world convened at the Fourth Aegean Conferences Workshop on Complement Associated Diseases, Animal Models, and Therapeutics (June 10-15, 2007), to discuss recent advances in this fast evolving field. This volume represents a collection of topics on the “novel” functions of complement, patho-physiology, protein structures, design of complement inhibitors, and complement assays discussed during the conference.

Biomedicine. --- Immunology. --- Microbiology. --- Infectious Diseases. --- Pathology. --- Medicine. --- Emerging infectious diseases. --- Médecine --- Immunologie --- Maladies infectieuses émergentes --- Pathologie --- Microbiologie --- Complement (Immunology) -- Congresses. --- Complement (Immunology). --- Complement (Immunology) --- Immunoproteins --- Immune System Processes --- Publication Formats --- Blood Proteins --- Publication Characteristics --- Immune System Phenomena --- Proteins --- Phenomena and Processes --- Amino Acids, Peptides, and Proteins --- Chemicals and Drugs --- Complement System Proteins --- Congresses --- Complement Activation --- Medicine --- Biology --- Health & Biological Sciences --- Medical Research --- Microbiology & Immunology --- Natural immunity --- Disease resistance --- Host resistance --- Innate immunity --- Innate resistance --- Native immunity --- Natural resistance --- Nonspecific immunity --- Resistance to disease --- Alexin --- Complements (Immunity) --- Infectious diseases. --- Microbial biology --- Microorganisms --- Disease (Pathology) --- Medical sciences --- Diseases --- Medicine, Preventive --- Immunobiology --- Life sciences --- Serology --- Clinical sciences --- Medical profession --- Human biology --- Pathology --- Physicians --- Immunity --- Blood proteins --- Emerging infections --- New infectious diseases --- Re-emerging infectious diseases --- Reemerging infectious diseases --- Communicable diseases

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Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements, responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation.